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Overall Evidence for the Use of B12 for Painful Peripheral Polyneuropathy Taking into account the above evidence, there is level III evidence overall to support the use of B12 either as monotherapy or as a combination therapy for treating neuropathic pain caused by peripheral polyneuropathy
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Its FDA-approval history, enhanced structural stability, and clinical evidence base (47 trials and counting) make it the gold-standard GHRH analog for metabolic research
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