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Pain relief usually begins within 3 days and peaks around 3 weeks
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These were in the cerebellum (ibuprofen [238], paracetamol [239]), the cerebral cortex (diclofenac [240,241], celecoxib [201]), the frontoparietal cortex (concussive brain trauma) [231], the hippocampus and the cerebral cortex (insulin) [242], and the parietal neocortex and the hippocampus (cuprizone [232])
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