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While these results clearly linked the action of AT 4 -receptor antagonists to the HGF/c-Met system, they did not provide a suitable explanation for the mechanism underlying the procognitive activity of AT 4 receptor agonists

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In human studies, IN administration of OT showed increased trust [95], positive communication [96], reduce cortisol and increase anxiolytic effects in stress [97], improved mind reading [98], and has a positive effect on social behaviors in both normal [99] and autistic persons [100,101]