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Indeed, several studies have indicated that VEGF may serve a maintenance role in vascularized tissues by inducing capillary fenestrations, as loss of VEGF has been shown to modulate fenestration stability in liver endothelial cells, pancreatic islet endothelial cells, and choroid plexus [41–43] and in promoting endothelial cell survival, as inhibition of VEGF leads to loss of alveolar, tracheal, and peritubular capillary endothelium [44–46]

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