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Apoptotic resistance resulting from NF-κB activation was eliminated because AEA reduced the phosphorylation of the inhibitor of the κB-kinase complex (Aun et al., 2011)

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Another possibility is that obesity could lower serum vitamin B12 levels through decreased dietary intake or absorption, increased catabolism, and sequestration in adipose tissue, or changes in the gut microbiota profiles which could affect the metabolism of vitamin B12