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Acknowledgement: The following funding supports the authors: NIH U54AG075931 (Melanie Koenigshoff, Toren Finkel, Aditi Gurkar, Nayra Cardenes), NIH R01HL168050 (Corrine Kliment, Melanie Koenigshoff), NIH R01HL161106 (Aditi Gurkar), Richard King Mellon Foundation (Aditi Gurkar, National Academy of Medicine CATALYST GRANT (Aditi Gurkar), NIH R61AG095927 (Corrine Kliment, Melanie Koenigshoff), Parker B Francis Fellowship (Richard Ramonell), VA | Geriatric Research Education and Clinical Center (GRECC) (Melanie Koenigshoff), American Federation for Aging Research (AFAR) (Aditi Gurkar)