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In human tri-culture systems comprising induced pluripotent stem cell (iPSC)-derived motor neurons, astrocytes, and microglia, RIPK1 activation modulated cytokine profiles, several of which mirrored increases or decreases in the cerebrospinal fluid (CSF) of ALS patients (Zelic et al., 2025)
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Meyer, T., Munch, C., Volkel, H., Booms, P