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We have also recently reported that GRK4 increases the phosphorylation of angiotensin II type 2 receptor (AT 2 R) which impairs renal AT 2 R-mediated diuresis and natriuresis, which participate in the GRK4-mediated regulation of blood pressure [93].In addition to dopamine and Ang II receptors, GRK4 also regulates other receptors such as the endothelin type B receptor (ETBR) and AdipoR1