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Beyond excitatory inputs, disturbances are also noted in inhibitory neurons within the PFC, including deficits in transcript levels for the Gamma-aminobutyric acid-synthesizing enzyme glutamate decarboxylase (GAD67) 71,72 and lower mRNA levels for the calcium-binding protein parvalbumin (PV) 73,74

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In practice, most interest clusters around these real world goals: Skin quality and visible aging Wound healing support (when appropriate), which aligns with the principles of regenerative therapy Hair and scalp health conversations (still evolving, mixed quality evidence) Joint, tendon, connective tissue support as part of a bigger plan Recovery support, again in context And for some patients, the “longevity” benefit is simply this: better tissue repair capacity and less chronic inflammatory signaling can improve quality of life