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In addition, acute and chronic treatment of mice with caffeine reduced the effect of acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) (Chen et al., 2001) and 6-hydroxydopamine (6-OHDA) treatment on striatal DA loss (Joghataie et al., 2004)

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The intracellular concentration of L-glutamine range from 2 mM to 20 mM [2], where as its concentration in extracellular fluid and plasma is about 0.7 mM (4, 5)