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This degradation, in turn, allows NF-κB activity to increase, resulting in increased transcription of pro-inflammatory genes, including TNF-α, IL-1β, IL-6, and inducible nitric oxide synthase (iNOS) ( In addition to the NF-κB pathway, the mitogen-activated protein kinase (MAPK) signaling cascade is also an important regulator of inflammatory responses in CNS microglia
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