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The regulatory circuitry responsible to modulate mitochondrial biogenesis in response to developmental and physiological cues is composed of transcriptional coactivators, such as members of the peroxisome proliferator-activated receptor γ coactivator-1 (PGC-1) family, and transcription factors, including the nuclear respiratory factors 1 (NRF-1) and 2 (NRF-2) (Fig
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