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Dr. David Perlmutter '76 Discusses Findings of Best-Selling Book on PBS · News · Lafayette College
The results showed that tetrahydrocurcumin treatment significantly reversed the H/R-induced increase in Bax/Bcl-2 expression, enhanced intracellular SOD and CAT activities, decreased the ratio of LC3-II/LC3-I in cardiomyocytes, downregulated the expression of Beclin-1, effectively enhanced the antioxidant capacity of cells and inhibited the apoptosis and autophagy events of cardiomyocytes
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In addition, Gpx1 preferentially scavenges H 2 O 2 and Gpx4 is mostly involved in the elimination of lipid hydroperoxides
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