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Tanycytes in the ME further facilitate BBB transcytosis of circulating peptides [948], and while this may be crucial for liraglutide to inhibit food intake [949], no such transport has yet been demonstrated for GIP
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Selective deletion of Keap1 in Clara cells in mouse lungs elevated the expression of Nrf2-dependent genes ( Nqo1 and Gclm ), increased the total level of glutathione in the lungs, protected Clara cells against oxidative stress ex vivo, and protected the lungs against oxidative stress and CS-induced inflammation in intact animals (138)
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