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15 There is a consensus that CMS (or Monge’s disease) and HAPH are the most common forms of chronic altitude illness (Fig

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[86] showed that the reduction of GPx-1 activity in silenced human endothelial cells for GPx1 expression accelerated oxidative stress and increased nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB) and c-Jun-N-terminal kinase (JNK) activation