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Furthermore, our findings indicated that circCDK13 is protected within intact sEVs as evidenced by the fact that treatment of circCDK13 OE -sEVs with RNase A/T1 mix did not reduce the level of circCDK13, whereas co-treatment of circCDK13 OE -sEVs with 1% Triton X-100, which could degrade sEVs membranes, induced a decrease of circCDK13 within the sEVs (Fig
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