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Type 1 diabetes (T1D) results from the complete autoimmune mediated destruction of the insulin producing beta (β) cells within the pancreatic islets ( The incidence of T1D and T2D have been exponentially increasing in recent decades, with the global prevalence predicted to reach almost 600 million cases by 2035 ( Interestingly, macrophages have been identified as the key players in both the modulation of host responses during helminth infections ( vice versa
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The proposed mechanism can be summarized as follows: The flow of this signaling pathway is shown below: Proposed pathway for this compound-induced autophagy via AMPK/mTOR
