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Clinical trials of semaglutide showed participants lost 10–22% of their body weight over 68 weeks, depending on the dose and individual metabolic response
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In obese adipose tissue, excessive ROS production from NADPH oxidases and impaired ETCs induces mitochondrial DNA (mtDNA) damage, which escapes into the cytoplasm and circulation as damage‐associated molecular patterns (DAMPs), activating TLR9 and NLRP3 inflammasome pathways to trigger pro‐inflammatory cytokine cascades such as IL‐1β and IL‐18 [118, 119]