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Clinical studies have shown KPV's half-life ranges from 2-4 hours when administered subcutaneously, requiring daily dosing for sustained therapeutic effects
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Adding Norethisterone on top of the combined pill is not appropriate, both contain progestogens, and stacking them increases the risk of side effects such as breakthrough bleeding, mood changes, and a small but real raised risk of venous thromboembolism (VTE)
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