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In addition, the necroptosis inhibitor necrostatin-1 has off-target activity, which can suppress ferroptosis at high concentrations (Friedmann Angeli et al., 2014), but this is unrelated to necroptosis
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Glaucoma, a leading cause of blindness characterized by progressive loss of retinal ganglion cells (RGC) and the corresponding visual field, has been associated to ocular inflammation, especially for primary open angle glaucoma (POAG) and normal tension glaucoma (NTG) ( Age-related macular degeneration (AMD), the most common cause of irreversible vision impairment in aged population in developed countries, is characterized by retinal pigment epithelium (RPE) damage, extracellular drusen, death of photoreceptors, and neovascularization ( Ocular surface diseases are heterogeneous and many of them share a common characteristic of inflammation including dry eye
