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Bacillota account for up 65% of the composition of the gut microbiota, with Bacteroidota—16%, Actinomycetota (older name Actinobacteria)—9%, and Pseudomonadota (older name Proteobacteria)—5% (Scheithauer et al., 2016

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The results of Western blotting showed that the inhibitor could counteract the promoting effect of GDF11 on the phosphorylation of the PI3K-AKT-eNOS signaling pathway (Fig