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Furthermore, iron is critical for energy metabolism due to its contribution to (1) heme-containing enzymes such as cytochrome c (in the electron transport chain) and cytochrome c oxidase (in the oxidative phosphorylation pathway) as well as (2) non-heme-containing enzymes including NADH dehydrogenase and succinate dehydrogenase (in the respiratory chain) and aconitase (in the Kreb’s cycle) [48]