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LEF-1 expression has been previously utilised as a marker in different tumour entities like acute lymphoblastic leukaemia, oral squamous cell carcinoma, and colorectal cancer to identify Wnt/β-catenin activated tumours ( Activating mutations in genes of the Wnt/β-catenin pathway occur in many solid tumour entities like colorectal cancer ( CTNNB1 , ZNRF3 , APC or Axin1 genes in most cases
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