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Left panel : Low-dose IV ACh primarily activates endothelial M3 muscarinic receptors, stimulating nitric oxide (NO) release and vascular smooth muscle relaxation, resulting in arterial vasodilation and reduced blood pressure

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Why this dose+ Reached in phase 2 by a different ladder: 0.6 mg start, doubling every 2 weeks (0.6 → 1.2 → 2.4 → 4.5)