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However, the majority of validated GERD questionnaires use symptom-based questions similar to those in this study 35 and guidelines by the American College of Gastroenterology 36 support the clinical use of subjective symptoms and response to antacid therapy as a method of GERD diagnosis

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A particular point is a very safe profile (LD1 could be not achieved) [7,16], a point recently confirmed in a large study of the Xu and collaborators [83]

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