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Activated AFs are also able to form Schiff bases with cellular and microsomal proteins (via methionine, histidine and lysine), thus leading to acute toxicity [128]
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Furthermore, PAS staining revealed more severe renal pathology in the Fsp1 fl/fl Ksp Cre-ERT2 groups, characterized by greater tubular necrosis, dilation and higher injury scores (Fig
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