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Mild injection site reactions, transient flushing, and gastrointestinal effects are commonly reported

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When comparing the FZD7-G s structure with the inactive FZD4 (PDB: 6BD4) [115] and FZD5 (PDB: 6WW2) [15], there was a notable outward curvature of TM6 and an inward displacement of TM5 on the cytoplasmic side