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Yang et al., Nature Genet., 7:362-369 (1994)

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Generally, CUR exhibits its antioxidant property through AMPK/Nrf2/ARE/Keap1 pathway activation, its anti-inflammatory property via NF-κB/AP-1/MAPK pathways inhibition, and its anti-apoptosis property by blocking JAK/STAT and ER stress-induced pathways while activating PI3K/AKT/mTOR pathways in non-cancerous diseases ( Figure 1 )