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The term scatter factor was later introduced independently in 1985 by Stoker and co-workers, as they discovered a protein interrupting the intracellular junctions of epithelial cells thereby promoting their migration in a paracrine manner and promoting an invasive phenotype [4]

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Studies using genetically altered models with defective NADPH oxidase activity have shown that NADPH oxidase plays a crucial role in angiotensin II signaling, contributing to cardiac hypertrophy and interstitial fibrosis