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However, overexpression of PGC-1α reduces autophagy marker levels, improves mitochondrial metabolic function and antioxidant capacity, thereby alleviating muscle atrophy, offering a potential approach to age-related sarcopenia ( Overexpression of the mitochondrial T3 receptor (p43) has also been shown to induce lipid peroxidation and lead to muscle atrophy
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His symptoms were persistent, although a physical exam was unremarkable
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