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In addition, the R152 3.50 A mutation decreased the efficacy of G protein signaling to 30% and the potency by over 3-fold that of the wild-type, while I156 3.54 A, Q166 ICL2 A, and L335 6.37 A reduced CCK-8 efficacy by 50% but did not affect the potency (Fig

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Research protocols show that after single-dose administration, more than half of senescent cells disappear while healthy cells remain intact, providing researchers with quantitative measures of senolytic efficacy