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For the outcome of weight loss (%), the meta‐analysis by Pan et al., which included studies with patients with and without DM, demonstrated that tirzepatide 15 mg once‐weekly led to significant weight loss compared with placebo, with a MD of −14.80% (95% CI: −17.39 to −12.20) [12]

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TF overexpression has also been shown to enhance cancer cell growth by increasing VEGF transcription and reducing thrombospondin transcription [109]