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A study by Melenovská et al (78) showed that administration of heme arginate restored heme binding, improved tetramer formation and enhanced catalytic activity of the CBS enzyme in several B6-resistant mutants
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With respect to the anti-inflammatory role of estradiol, it has been demonstrated that ovariectomized female mice on HFD exhibit increased levels of hepatic macrophage infiltration, along with pro-inflammatory cytokines (IL-1β, IL-6) and chemokine (CCR2), compared to controls (sham-operated mice) (265, 266)
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