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Research published in Interface Focus confirms that agitation-induced aggregation is a documented degradation pathway for peptides in solution

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These distal sequelae are precipitated via abrogation of flux through the mevalonate biosynthetic conduit, wherein attrition of isoprenoid derivatives engenders perturbation of lipid-anchorage-dependent spatial disposition and the operational competency of low-molecular-weight GTP-binding modulators such as Rho, Rac, and Ras (Figure 3) [48,49,50]