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One-carbon metabolism requires B vitamins, and hence the efficient dietary supply may protect against cancer by reducing DNA instability and by affecting DNA methylation [42], but vitamin B12, methylcobalamin, and coenzyme B12 were found to enhance DNA methylation in the presence of S-adenosylmethionine for concentrations up to 1 μM, but at higher concentrations, these compounds were found to inhibit DNA methylation [43]