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Explored for potential links to nerve regeneration, angiogenesis in neural tissue, and gene expression patterns associated with repair and ageing
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Iron-aminoglycoside complexes catalyze Fenton reactions, converting hydrogen peroxide to highly reactive hydroxyl radicals that damage lipids, proteins, and DNA ( Cochlear hair cells possess limited intrinsic antioxidant capacity, with lower glutathione (GSH) concentrations and reduced catalase activity relative to many other cell types, and a restricted ability to regenerate reduced GSH from oxidized forms ( Calcium dysregulation amplifies oxidative injury through a bidirectional positive feedback loop