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Another study reported that piperine inhibits LPS-induced expression and production of pro-inflammatory cytokines IL-1β, IL-6, IL-10 and TNFα by inhibiting NF-κB activation (Dzoyem et al., 2017)
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In FXS, CGG repeat expansions in the FMR1 gene lead to the loss of FMRP, impairing the translation of GABAA receptor mRNAs, particularly the GABAA α5 subunit, reducing receptor density in the amygdala and nucleus accumbens, resulting in delayed language development and autistic-like behaviors (138)