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Cysteine S -conjugates taken up within the liver are thought to be converted to the corresponding mercapturates and secreted to the plasma to be eventually excreted in the urine (Inoue et al., 1981, Inoue et al., 1982, Inoue et al., 1987)

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Cytosolic and nuclear fractionation was carried out by subcellular protein fractionation kit for cultured cells (Thermo scientific) according to manufacturer’s instruction