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References Nature Communications Biology — FOXO4-DRI induces keloid senescent fibroblast apoptosis by promoting nuclear exclusion of upregulated p53-serine 15 phosphorylation Nature Cell — Targeted apoptosis of senescent cells restores tissue homeostasis in response to chemotoxicity and aging (original FOXO4-DRI discovery) Aging (Albany NY) — FOXO4-DRI alleviates age-related testosterone secretion insufficiency by targeting senescent Leydig cells in aged mice Journal of Cellular and Molecular Medicine — FOXO4 peptide targets myofibroblast ameliorates bleomycin-induced pulmonary fibrosis in mice Cell — Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice (senolytic mechanism context) Aging (Albany NY) — Methods & Protocols — FOXO4-DRI safety note: no human clinical dosing data exist yet PubMed — A liquid chromatography high-resolution mass spectrometry in vitro assay to assess metabolism at the injection site of subcutaneously administered therapeutic peptides Bachem — Care and Handling of Peptides (storage, reconstitution, stability guidance) MedlinePlus — Subcutaneous (SQ) injections: technique, site selection, and safety American Diabetes Association — Insulin injection site rotation and lipohypertrophy prevention CDC — Vaccine administration: subcutaneous route (angle, site
