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The peptide was developed in the late 1990s and early 2000s with the explicit goal of separating the fat-mobilising activity of growth hormone from its other physiological effects, particularly its effects on IGF-1 production and insulin sensitivity
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Mice received a 5-min block of no stimulation (off) followed by the delivery of the optostimulation pattern (on) for 30 minutes (see Optogenetic stimulation protocol section)
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