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Moreover, an investigation into the mode of action of TQ in androgen receptor (AR)-naïve (PC-3) and AR-independent (C-2B) PCa cells revealed that TQ inhibited the growth of human prostate C-2B cancer cells by inducing growth arrest, JNK activation, and DNA-damage-inducible 45 alpha (GADD45a), while also downregulating Bcl-2-related proteins, such as BAG-1, Bcl-2, Bcl2A1, Bcl2L1, and BID
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