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Exploring the Promise of Targeting Ubiquitin-Proteasome System to Combat Alzheimer's Disease | Neurotoxicity Research | Springer Nature Link

doi: 10.1158/0008-5472.CAN-05-4533 65 CalmelsSHainautPOhshimaH

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High-resolution structures of pathogen-derived enzymes suitable for selective linker activation are available for only a small fraction of relevant targets ( in vivo measurements describing infectious microenvironments, including pH gradients in granulomas, redox conditions within parasitized phagosomes, and protease activity in bacterial biofilms, which are often inferred rather than directly measured (Miwa et al., 2023)