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In a large cohort of healthy women attempting conception ( n = 1209 cycles), higher urinary isoflavones were not associated with meaningful changes in cycle length but were linked to lower odds of menstrual irregularity (OR 0.79, 95% CI 0.64–0.98), whereas higher lignan excretion showed slightly increased irregularity risk (OR 1.32, 95% CI 1.06–1.64) [163]

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Additionally, the peptide demonstrated a relatively good safety profile in controlled trials