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individuals with pre-existing retinopathy should be aware of this risk [28] [29] Pregnancy and breastfeeding — incretin-based therapies should be avoided during pregnancy and breastfeeding unless within a supervised clinical trial, as safety data in these populations are absent Delayed gastric emptying — a class effect of GLP-1 receptor agonists — can reduce the absorption rate of concomitant oral medicines

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It reduces Cu2+ to Cu+, disrupting the GHK-Cu chelate and producing free copper ions and dehydroascorbate