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This review aims to summarize all aberrant methylation alterations in ESCC and the clinical implications of aberrantly methylated candidate genes identified in ESCC systemic chemotherapy, with the goal of further understanding the underlying molecular mechanisms, refining methylation-targeting therapies, and integrating them with conventional treatments to improve patient outcomes

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In addition, relative to the Control group, there was a notable elevation in the level of MDA in the IS group ( P 0.05) (Figures 7B–D)