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Epithelial-mesenchymal transition (EMT) is the process by which epithelial cells acquire the ability to migrate and invade through downregulating proteins like E-cadherin and γ-catenin and expressing mesenchymal markers like MMPs, N-cadherin, and vimentin
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We have to note that the IP receptor antagonist CAY10441and the COX2 inhibitor NS398 had significant inhibitory effects only during the early phase of neuropathic pain, and that the antagonism of COX2 and PGI2 transiently and modestly altered the withdrawal thresholds of mechanical hypersensitivity
