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Human data shows GHRP-6 needs endogenous GHRH tone to reach maximal GH stimulation (Pandya et al., J Clin Endocrinol Metab, 1998, PMID 9543138), and Bowers' original work found the combination acts synergistically: GHRP plus GHRH releases more GH than the sum of either alone (PMID 2108187)

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