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Concurrently, introducing the heat shock protein (HSP70iQ435A) plasmid into vitiligo mouse models and Sinclair pigs to interfere with endogenous HSP70i signals successfully reversed depigmentation in the model animals (Zhang et al., 2021b).Furthermore, oxidative stress can promote the expression of NACHT and LRR in melanocytes, further activating the caspase cascade and leading to the secretion of inflammatory cytokines such as IL-1β and IL-18
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