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Interestingly, Bottari and colleagues reported even higher circulating markers of oxidation (MDA and AOPP) after CHOP chemotherapy (cyclophosphamide, vincristine, doxorubicin, and prednisone) in dogs with multicentric lymphoma, suggesting that the treatment might exacerbate OS levels [74]

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Upon adenosine diphosphate (ADP) activation, the P2RY12 receptor interacts with Gi and inhibits adenylate cyclase activity (168)