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Trials will need to follow endocrine shifts, reproductive results, and off-target implications for years, not weeks
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This is due to a phenomenon termed plasma skimming, in which erythrocytes that are primarily in the center of vessels continue to flow in the interlobular artery towards the superficial cortex, while the plasma in the periphery of the capillary is captured by the juxtamedullary afferent arterioles and ultimately flows into vasa recta
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